GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9309473 | 1 | rs56154726 | chr2:73721767 | ALMS1P | chr2:73872046-73912692:+ | 0.34 | 4.94 | 1.2E-6 | Metabolite levels |
| BLCA | cis | rs9815354 | 1 | rs56158380 | chr3:41885588 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.5 | 2.29E-19 | Diastolic blood pressure |
| BLCA | cis | rs60843830 | 1 | rs56167434 | chr2:282137 | SH3YL1 | chr2:218138-264810:- | -0.46 | -12.24 | 2.68E-29 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs9815354 | 1 | rs56207540 | chr3:41976627 | ULK4 | chr3:41288091-42003660:- | 0.63 | 8.28 | 2.12E-15 | Diastolic blood pressure |
| BLCA | cis | rs2243480 | 1 | rs56291018 | chr7:65390339 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 4.47 | 1.02E-5 | Diabetic kidney disease |
| BLCA | cis | rs60843830 | 1 | rs56321614 | chr2:268191 | SH3YL1 | chr2:218138-264810:- | -0.44 | -11.55 | 1.15E-26 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs56322409 | 1 | rs56322409 | chr10:97395962 | ENTPD1 | chr10:97471536-97637022:+ | 0.19 | 4.94 | 1.15E-6 | Blood metabolite levels |
| BLCA | cis | rs55883249 | 1 | rs56372340 | chr2:9741536 | ADAM17 | chr2:9629413-9695917:- | -0.19 | -3.98 | 8.35E-5 | 3-hydroxy-1-methylpropylmercapturic acid levels in smokers |
| BLCA | cis | rs8102137 | 1 | rs56400371 | chr19:30299634 | CCNE1 | chr19:30302901-30315218:+ | 0.21 | 3.95 | 9.39E-5 | Bladder cancer |
| BLCA | cis | rs477692 | 1 | rs565974 | chr10:131423274 | MGMT | chr10:131265454-131565783:+ | 0.22 | 4.88 | 1.57E-6 | Response to temozolomide |
| BLCA | cis | rs9309473 | 1 | rs56672945 | chr2:73622663 | ALMS1P | chr2:73872046-73912692:+ | 0.33 | 4.87 | 1.65E-6 | Metabolite levels |
| BLCA | cis | rs477692 | 1 | rs567700 | chr10:131423126 | MGMT | chr10:131265454-131565783:+ | 0.22 | 4.88 | 1.57E-6 | Response to temozolomide |
| BLCA | cis | rs9815354 | 1 | rs56776628 | chr3:41866856 | ULK4 | chr3:41288091-42003660:- | 0.62 | 9.66 | 6.48E-20 | Diastolic blood pressure |
| BLCA | cis | rs568617 | 1 | rs568617 | chr11:65653242 | CTSW | chr11:65647284-65651212:+ | -0.6 | -9.06 | 6.99E-18 | Crohn's disease |
| BLCA | cis | rs568617 | 1 | rs568617 | chr11:65653242 | SNX32 | chr11:65601410-65621170:+ | 0.34 | 4.75 | 2.91E-6 | Crohn's disease |